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采用镉还原柱层析和比色法测定了42例哮喘患儿外周血亚硝酸/硝酸根离子(NO_2~-/NO_3~-)水平,另用生物学活性法测定了白细胞介素2、4、6(IL-2、4、6)及肿瘤坏死因子(TNF)水平.结果:小儿哮喘发作期外周血IL-2、4、6,TNF及NO水平均明显高于正常儿童(P分别<0.05,<0.01);在缓解期IL-2,6,NO水平恢复正常水平(P均>0.05),而IL-4,TNF水平虽较发作期有明显降低,但仍高于正常儿童(P均<0.01).提示:NO,IL-2、4、6及TNF参与了哮喘的病理生理过程,是哮喘气道高反应性及变应性炎症的重要介质,在哮喘的免疫发病机制中占有重要地位.
The levels of nitrite / nitrate (NO 2 - / NO 3 -) in peripheral blood of 42 asthmatic children were measured by cadmium reduction column chromatography and colorimetry. The biological activity of interleukin 2, 4 , 6 (IL-2, 4, 6) and tumor necrosis factor (TNF) in children with asthma.Results: The levels of IL-2,4,6, TNF and NO in peripheral blood of children with asthma were significantly higher than those of normal children (P < 0.05, <0.01). In the remission stage, the level of IL-2,6 and NO returned to normal (P> 0.05), while the level of IL-4 and TNF decreased significantly All <0.01) .It is suggested that NO, IL-2, 4, 6 and TNF are involved in the pathophysiological process of asthma and are important mediators of airway hyperresponsiveness and allergic inflammation in asthma and occupy the immune pathogenesis of asthma important position.