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血红蛋白由血红素和珠蛋白组成,而珠蛋白由二对肽链构成,由于血红蛋白分子结构变异所引起的病理变化称为血红蛋白病.1979年我国20个省市20个民族60多万人口普查,发现高发区为广东、广西、江西、新疆等地.血红蛋白病可分为二类,一类是珠蛋白肽链量的异常,称为地中海性贫血(Thalassancmia,TA);另一类是珠蛋白肽链结构异常,称为异常血红蛋白病.TA 若困α或β基因异常又称为α或βTA,其中对胎儿影响最大的为αTA.αTA 系常染包体不
Hemoglobin is composed of hemoglobin and globin, while globin is composed of two pairs of peptide chains, and the pathological change due to structural variation of hemoglobin is called hemoglobinopathies. In 1979, there were more than 600,000 population censuses of 20 ethnic groups in 20 provinces and cities in China, It is found that the high incidence areas are Guangdong, Guangxi, Jiangxi, Xinjiang, etc. Hemoglobinopathies can be divided into two categories, one is the abnormality of the amount of globin chain, which is called Thalassancmia (TA), the other is globin Abnormal structure of the peptide chain, known as abnormal hemoglobin disease .TA if sleepy α or β gene abnormalities, also known as α or βTA, of which the greatest impact on the fetus αTA.