芥子气属糜烂性毒剂,具有强大的杀伤效应,目前仍是外军主要装备的化学毒剂之一。迄今为止,尚无芥子气的特效抗毒剂,仅采用对症和支持疗法。芥子气诱发细胞凋亡的分子机制是近年来其毒理学研究领域的热点,本文综述了该领域的研究进展,以期为全面认识芥子气凋亡机制及制订有效的凋亡干预策略提供思路。 Mustard gas is a decadent poison, with a strong lethal effect, and is still one of the major chemical agents used by foreign troops. To date, no effective antidote for mustard has been used, only symptomatic and supportive therapies. The molecular mechanism of mustard gas-induced apoptosis is a hot area in the field of toxicology research in recent years. This review summarizes the research progress in this field, with a view to providing ideas for fully understanding the mechanism of mustard gas apoptosis and formulating an effective apoptosis intervention strategy.