论文部分内容阅读
目的:探讨慢性心力衰竭患者血浆B型利钠肽(BNP)、心钠素(ANF)、胱抑素C(CysC)的水平及临床意义。方法:选择70例CHF患者,按NA分级;20例健康者作为对照。采用放射免疫法检查BNP和ANF水平;采用免疫比浊法检查Cys C。比较不同心衰等级以及不同BNP水平的上述指标的变化。结果:CHF患者血浆BNP、ANF、CysC水平与对照比较显著升高(P<0.05),并随NYHA等级增高而升高(P<0.05)。与BNP<400pg/ml组比较,400pg/ml≤BNP<800pg/ml组和BNP≥800pg/ml组心力衰竭患者Cr、BUN水平显著增高(P<0.05);相反地,HDL水平显著降低。结论:血浆B型利钠肽(BNP)、心钠素(ANF)及胱抑素C参与了CHF的发生发展过程,联合测定其含量的变化,对CHF患者的诊断、评估及危险分层具有一定的临床意义。
Objective: To investigate the levels of plasma B-type natriuretic peptide (BNP), atrial natriuretic peptide (ANF) and cystatin C (CysC) in patients with chronic heart failure and their clinical significance. Methods: Seventy patients with CHF were selected and graded according to NA. Twenty healthy subjects served as controls. BNP and ANF levels were examined by radioimmunoassay; Cys C was examined by immunoturbidimetry. Comparison of different grades of heart failure and BNP levels of these indicators of changes. Results: The plasma levels of BNP, ANF and CysC in CHF patients were significantly higher than those in controls (P <0.05), and increased with NYHA grade (P <0.05). Compared with BNP <400pg / ml group, Cr and BUN levels in heart failure patients with 400pg / ml≤BNP <800pg / ml and BNP≥800pg / ml were significantly increased (P <0.05); Conversely, HDL levels were significantly decreased. Conclusions: Plasma BNP, ANF and cystatin C are involved in the development and progression of CHF, and the changes of the content of CHF are associated with the diagnosis, assessment and risk stratification of CHF patients. Certain clinical significance.