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目的比较miR-148a在膀胱癌(BCa)组及正常对照组中的相对表达水平,并进行临床意义的初步探讨。方法2011年-2013年采集于浙江大学医学院附属第二医院泌尿外科诊疗中心BCa患者标本52例为膀胱癌组,同时选正常对照组24例,用RT-PCR对产物进行反转录反应和扩增,分析miR-148a在膀胱癌组和正常对照组结果之间的差异并做比较。结果膀胱癌组标本中miR-148a的表达水平明显高于正常对照组,差异有统计学意义(Z=-6.358,P<0.05);BCa组患者病理分级越高,miR-148a在癌组织中的表达升高越明显,差异有统计学意义(χ~2=22.163,P<0.05);Ⅱ级与Ⅲ级、Ⅰ级与Ⅲ级之间比较差异均有统计学意义(Z值分别为-3.447、-3.67,P<0.05)。膀胱癌伴肿瘤浸润组(T2)的miR-148a表达明显高于非浸润组(Tis原位癌+T1),差异有统计学意义(Z=-3.37,P<0.05)。结论miR-148a可能在BCa的病理分级和临床分期中有着一定的作用,为miR-148a在BCa肿瘤形成及肿瘤治疗方面提供了新的视点。
Objective To compare the relative expression level of miR-148a in bladder cancer (BCa) group and normal control group, and to explore the clinical significance. Methods 52 cases of BCa collected from Department of Urology, Second Hospital Affiliated to Medical College of Zhejiang University from 2011 to 2013 were selected as bladder cancer group and 24 cases of normal control group. Reverse transcription reaction The differences between miR-148a in bladder cancer group and normal control group were analyzed and compared. Results The expression of miR-148a in bladder cancer specimens was significantly higher than that in normal controls (Z = -6.358, P <0.05). The pathological grade of BCa patients was higher, and the expression of miR-148a in cancer tissues The difference was statistically significant (χ ~ 2 = 22.163, P <0.05). There was significant difference between grade Ⅱ and grade Ⅲ, grade Ⅰ and grade Ⅲ (Z values were - 3.447, -3.67, P <0.05). The expression of miR-148a in bladder cancer with tumor infiltration group (T2) was significantly higher than that in noninvasive group (Tis carcinoma in situ + T1), the difference was statistically significant (Z = -3.37, P <0.05). Conclusion miR-148a may play a role in the pathological grading and clinical stage of BCa, providing a new perspective for miR-148a in BCa tumorigenesis and oncology treatment.