为研究必需元素在镉致睾丸脂质过氧化损伤中的作用 ,用氯化镉对成年雄性SD大鼠进行腹腔染毒 ,观察睾丸中必需元素、超氧化物歧化酶 (SOD)及丙二醛 (MDA)的变化情况。结果显示 ,高剂量组锌含量、SOD活性显著降低 ,铁、钙及MDA含量显著升高。提示 ,镉染毒后睾丸中必需元素如锌和铁可能通过影响抗氧化酶的活性或直接参与催化自由基的形成等机制引起自由基产生增多 ,诱发脂质过氧化 In order to study the role of essential elements in cadmium-induced testicular lipid peroxidation injury, adult male Sprague-Dawley rats were intraperitoneally exposed to cadmium chloride. The contents of essential elements, superoxide dismutase (SOD) and malondialdehyde (MDA) changes. The results showed that high-dose group of zinc content, SOD activity was significantly reduced, iron, calcium and MDA levels were significantly increased. It is suggested that the essential elements such as zinc and iron in the testes after cadmium exposure might induce the increase of free radicals by inducing the activity of antioxidant enzymes or directly participating in the formation of catalytic free radicals and induce lipid peroxidation