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HBX抗原是乙肝病毒最小编码框X基因区编码的蛋白 ,研究证明它与HBV相关性肝癌的发生有关 ;抑癌基因p5 3的变异或失活也与肝细胞癌 (HCC)的发生密切相关。研究HBX抗原与 p5 3的相互作用关系 ,有助于进一步揭示HBV相关性肝癌的发病机制。
HBX antigen is a protein encoded by the X-coding region of the minimal coding region of hepatitis B virus. Studies have shown that it is associated with the development of HBV-related hepatocellular carcinoma. Mutation or inactivation of the suppressor gene p5 3 is also closely related to the occurrence of hepatocellular carcinoma (HCC). Studying the interaction between HBX antigen and p5 3 will help further reveal the pathogenesis of HBV-related hepatocellular carcinoma.