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目的:研究茶碱联合糖皮质激素治疗中度哮喘的临床效果。方法:回顾分析从2012年6月-2013年6月期间惠东县白花镇卫生院收治的中度哮喘患者40例。将40例患者随机分为观察组和对照组。观察组(n=20)采用茶碱联合糖皮质激素治疗,对照组(n=20)采用β2受体激动剂联合糖皮质激素治疗。比较两组患者的治疗效果、晨晚间呼气流量峰值(PEF)和一秒率(FEV1%)。结果:观察组与对照组患者经过治疗后症状均得到改善,治疗前后哮喘症状评分比较,差异具有统计学意义(P<0.05)。治疗后,两组患者之间的症状评分、晨晚间呼气流量峰值(PEF)和一秒率(FEV1%)比较,差异无统计学意义(P>0.05)。结论:茶碱联合糖皮质激素能有效治疗中度哮喘,缓解症状,可以作为治疗中度哮喘的一种用药方案。
Objective: To study the clinical effect of theophylline combined with glucocorticoid in the treatment of moderate asthma. Methods: A retrospective analysis of 40 cases of moderate asthma admitted from Baihua Town Hospital of Huidong County from June 2012 to June 2013 was conducted. Forty patients were randomly divided into observation group and control group. The observation group (n = 20) was treated with theophylline combined with glucocorticoid, while the control group (n = 20) was treated with β2 receptor agonist combined with glucocorticoid. The treatment effect was compared between the two groups, peak morning expiratory flow (PEF) and one second rate (FEV1%). Results: The symptoms of the observation group and the control group were improved after treatment. The scores of asthma symptoms before and after treatment were significantly different (P <0.05). After treatment, there was no significant difference in symptom score, morning peak expiratory flow (PEF) and one second rate (FEV1%) between the two groups (P> 0.05). Conclusion: Theophylline combined with glucocorticoids can effectively treat moderate asthma and relieve symptoms, and can be used as a medication regimen for treating moderate asthma.