采用体外培养方法,对恶性疟原虫FCC-1/HN株入侵人红细胞进行了观察,结果为:1.人血型糖蛋白A在50及100μg/ml时抑制入侵率分别达91与100％;卵类粘蛋白在100μg/ml时抑制40％。2.红细胞用唾液酸酶或胰蛋白酶处理后,疟原虫入侵率减少33～37％。3.D-葡糖胺HCI、唾液酸及N-乙酰-D-葡糖胺有较强的抑制入侵作用,但无协同作用.4.麦胚凝集素在100μg/ml时表现明显的抑制效应。 In vitro culture of human erythrocytes against Plasmodium falciparum FCC-1 / HN was carried out and the results were as follows: 1. The inhibitory rates of invasion of human blood glycoprotein A were 91 and 100% at 50 and 100 μg / ml respectively; Mucin inhibits 40% at 100 μg / ml. After erythrocytes were treated with sialidase or trypsin, the parasite invasion rate was reduced by 33-37%. D-glucosamine HCI, sialic acid and N-acetyl-D-glucosamine have strong inhibition of invasion, but no synergistic effect.4. Wheat germ agglutinin showed significant inhibitory effect at 100μg / ml .