论文部分内容阅读
目的探讨同源结构域相互作用蛋白激酶2(HIPK2)在宫颈癌及宫颈癌前病变中的表达情况及其临床意义。方法应用免疫组织化学及RT-PCR技术检测宫颈癌组织24例、宫颈上皮内瘤变(CIN)24例及正常宫颈10例中HIPK2的表达情况,分析HIPK2与宫颈癌发病之间的关系。结果宫颈癌与其他各组HIPK2的表达均有明显差异(均P<0.05),CINⅢ与正常组也有明显差异(P<0.05),而CINⅠ～Ⅱ与正常组比较无明显差异(P>0.05),且HIPK2在宫颈癌组织、CINⅢ、CINⅠ～Ⅱ及正常宫颈中的表达呈递增趋势。结论HIPK2在宫颈组织中表达的减少可能是宫颈癌的发病原因之一。
Objective To investigate the expression of homology domain-interacting protein kinase 2 (HIPK2) in cervical cancer and cervical precancerous lesions and its clinical significance. Methods The expression of HIPK2 in 24 cases of cervical cancer, 24 cases of cervical intraepithelial neoplasia (CIN) and 10 cases of normal cervix was detected by immunohistochemistry and RT-PCR. The relationship between HIPK2 and the incidence of cervical cancer was analyzed. Results The expression of HIPK2 was significantly different between cervical cancer and other groups (all P <0.05), CINⅢ was also significantly different from that of normal group (P <0.05), while there was no significant difference between CINⅠ ~ Ⅱ and normal group (P> 0.05) , And the expression of HIPK2 in cervical cancer tissue, CINⅢ, CINⅠ ~ Ⅱ and normal cervix showed an increasing trend. Conclusion The decreased expression of HIPK2 in cervical tissue may be one of the causes of cervical cancer.