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近10年来,垂体腺瘤的研究在各方面有了飞跃的进展兹分述如下: 垂体前叶细胞学 晚近在垂体正常细胞与腺瘤细胞的组织学研究方面获得了丰富的资料。由于细胞染色方法的日益完善、电子显微镜的使用、细胞免疫荧光技术的进展,对细胞的超微结构、尤其是细胞胞浆分泌性颗粒的鉴定业已达到非常精细的程度,从而得以精确判定各种不同的细胞,并按其真正的分泌功能加以命名。现已公认,垂体前叶内存在6种分泌细胞,各自产生相应的一种垂体激素,诸如GH、PRL、ACTH和β-LPH、TSH、FSH及LH。其中后两种激素是否由同一种细胞分泌,尚无定论。Bloodworth认为,还应增加两种细胞:嗜酸性干细胞和未分化细胞。此外,还可偶见瘤细胞(Oncocy-tes)。至于嫌色性细胞,在正常垂体内可能
In the past 10 years, advances in the study of pituitary adenomas in various fields have been described as follows: Anterior pituitary cytology Recently, extensive information has been obtained on the histological studies of pituitary normal cells and adenoma cells. Due to the increasing perfection of cell staining methods, the use of electron microscopy, and the advancement of cellular immunofluorescence technology, the ultra-structure of cells, especially the identification of cytoplasmic secretory granules, has reached a very fine level, enabling accurate determination of various Different cells are named according to their true secretory function. It is now recognized that there are six secretory cells in the anterior pituitary, each producing a corresponding pituitary hormone, such as GH, PRL, ACTH and β-LPH, TSH, FSH and LH. Whether the latter two hormones are secreted by the same cell is inconclusive. Bloodworth believes that two types of cells should be added: eosinophilic stem cells and undifferentiated cells. In addition, Oncocy-tes can occasionally appear. As for chromophobe cells, it may be in normal pituitary