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目的:探讨原发性高血压患者的体液免疫功能及其临床意义。方法:随机选取我院住院的原发性高血压患者112人为实验组,以同期的健康体检者73人(排除继发性高血压及其他免疫系统疾病)为对照组,通过体液免疫系统指标测定,分析不同性别、年龄、病期、脉压差及不同并发症组各组患者体液免疫功能的变化。结果:与对照组相比较,男女原发性高血压患者IgG水平显著增高(P<0.05);且随着年龄的增长、病情的加重,血清IgG和IgA的含量及抗核抗体(ANA)和可提取核抗原抗体(ENA)检出率明显增加(P<0.05)。脉压差<60mmHg者IgG、IgA的水平显著高于对照组(P<0.05);并发有心脑血管损害者血清IgG和ANA的含量异常升高(P<0.05)。结论:原发性高血压患者存在着体液免疫功能异常,且与性别、年龄、病情的轻重、脉压差的大小及心脑血管并发症有密切关系。
Objective: To investigate the humoral immune function and its clinical significance in patients with essential hypertension. Methods: Randomly selected 112 hospitalized patients with essential hypertension in our hospital as the experimental group, with 73 healthy people (excluding secondary hypertension and other immune system diseases) in the same period as the control group. The indexes of humoral immune system , Analysis of different gender, age, disease duration, pulse pressure and different complications in each group of patients with humoral immune function changes. Results: Compared with the control group, IgG levels were significantly increased in patients with essential hypertension (P <0.05). With the increase of age, the severity of the disease, the levels of serum IgG and IgA and the levels of anti-nuclear antibody The detection rate of extractable nuclear antigen antibody (ENA) was significantly increased (P <0.05). The levels of IgG and IgA in patients with pulse pressure <60mmHg were significantly higher than those in control group (P <0.05). The levels of serum IgG and ANA in patients with cardiovascular and cerebrovascular damage were abnormally elevated (P <0.05). Conclusion: There are abnormalities of humoral immune function in patients with essential hypertension, and are closely related to gender, age, severity of illness, pulse pressure difference and cardiovascular and cerebrovascular complications.