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慢性阻塞性肺疾病(COPD)患者由于长期缺氧而出现继发性肺血管压力增高,长期氧疗可降低肺血管压力而改善这些患者的生存。近来研究照示吸入一氧化氮(NO)降低COPD患者的平均肺动脉压(mPAP)比氧疗更有效,尤其对经氧疗而效果不佳者。但吸入NO不能改善COPD患者的氧分压(PaO_2)。为了评价联合吸入NO和氧对COPD患者的mPAP和PaO_2的治疗效果,作者对10例COPD患者联合吸入NO和氧后mPAP和PaO_2的变化进行了分析。
Patients with chronic obstructive pulmonary disease (COPD) develop secondary pulmonary vascular pressure due to chronic hypoxia, and long-term oxygen therapy reduces pulmonary vascular pressure and improves survival in these patients. Recent studies have shown that inhaled nitric oxide (NO) reduces the mean pulmonary arterial pressure (mPAP) in patients with COPD more effectively than oxygen therapy, especially in patients who are refractory to oxygen therapy. However, inhaled NO does not improve the oxygen partial pressure (PaO 2) in patients with COPD. In order to evaluate the therapeutic effect of combined inhalation of NO and oxygen on mPAP and PaO 2 in patients with COPD, the authors analyzed the changes of mPAP and PaO 2 in 10 patients with COPD after combined inhalation of NO and oxygen.