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目的:阶段性回顾分析261个卵胞浆内单精子注射(ICSI)周期的实验室及临床结果。方法:收集1999年10月至2001年12月在本院生殖中心接受ICSI治疗的严重男性因素及不明原因不孕的患者261个治疗周期的资料,并分为两个阶段:1999年10月至2000年12月,2001年1月至2001年12月。分析比较两阶段的成熟卵母细胞率、受精率、卵裂率、Ⅰ级胚胎率、平均移植胚胎数、临床妊娠率、流产率和妊娠率与女方年龄的关系。结果:两阶段的成熟卵母细胞率、受精率、临床妊娠率分别为86.31％和91.00％,60.98％和73.50％,28.78％和38.52%,差异有统计学意义(P<0.05)。卵裂率、Ⅰ级胚胎率、平均移植胚胎数差异无统计学意义(P>0.05)。同时发现妇女年龄与临床妊娠率有关。结论:控制性超排卵获得高质量的卵子、女方年龄、ICSI的操作技术直接影响ICSI的胚胎质量,与妊娠率有密切关系。
Objective: To review the laboratory and clinical results of 261 intracytoplasmic sperm injection (ICSI) cycles in a phased manner. METHODS: The data of 261 treatment cycles of patients with severe male infertility and unexplained infertility who received ICSI at our reproductive center from October 1999 to December 2001 were collected and divided into two phases: from October 1999 to December 2001 December 2000, January 2001 to December 2001. The relationship between the two stages of mature oocyte rate, fertilization rate, cleavage rate, grade Ⅰ embryo rate, average number of transplanted embryos, clinical pregnancy rate, abortion rate and pregnancy rate were analyzed. Results: The two-stage matured oocyte rate, fertilization rate and clinical pregnancy rate were 86.31% and 91.00%, 60.98% and 73.50%, 28.78% and 38.52%, respectively, with statistical significance (P <0.05). Cleavage rate, grade Ⅰ embryo rate, average number of embryos transferred had no significant difference (P> 0.05). Also found that women’s age and clinical pregnancy rate. CONCLUSIONS: Controlled superovulation results in high quality eggs and the age of the woman. The technique of ICSI directly affects the quality of ICSI embryos, which is closely related to the pregnancy rate.