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[目的]评价GPA(graded prognostic assessment)分级在评价肺癌脑转移瘤患者预后中的作用。[方法]回顾性分析109例肺癌脑转移患者的临床资料,按GPA系统进行GPA评分,采用Kaplan-Meier进行生存分析并进行Log-rank检验。[结果]单因素分析显示患者的Karnofsky评分(KPS评分)、脑转移灶数目、颅外转移对肺癌脑转移患者生存期有影响(P<0.05)。GPA 0~1分组中位生存期为8个月(95%CI:4.64~11.36),1.5~2.5分组中位生存期12个月(95%CI:9.16~14.83),3~4分组中位生存期25个月(95%CI:5.87~44.13),不同GPA评分患者的中位生存期差异有统计学意义(χ2=7.467,P=0.024)。[结论]GPA作为一个预后模型,是有用的肺癌脑转移预测模型。
[Objective] To evaluate the effect of graded prognostic assessment (GPA) grade on the prognosis of patients with brain metastases of lung cancer. [Methods] The clinical data of 109 patients with brain metastases from lung cancer were retrospectively analyzed. The GPA scores were obtained according to GPA system. Kaplan-Meier method was used for survival analysis and Log-rank test. [Results] Univariate analysis showed that Karnofsky score (KPS score), number of brain metastases and extracranial metastases had an impact on the survival of patients with brain cancer with lung cancer (P <0.05). Median survival was 8 months (95% CI: 4.64 to 11.36) in the 0-1 GPA group, median survival time was 12 months (95% CI: 9.16-14.83) in the 1.5-2.5 group, The median survival time was 25 months (95% CI: 5.87-44.13). There was significant difference in median survival between different GPA scores (χ2 = 7.467, P = 0.024). [Conclusion] As a prognostic model, GPA is a useful predictive model for brain metastasis of lung cancer.