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所有疾病都有一个发生发展的过程 ,近年来意识到对抗原的免疫应答也是具有可塑性的 ,动态的 ,不断扩展的过程。免疫应答从针对某抗原分子的一个表位到多个表位 ,从某种抗原到其他抗原的逐渐多样化的现象被称为表位扩展 (epitopespreading)。表位扩展现象存在于多种疾病 ,尤其是自身免疫病的发生、发展和预后的过程中 ,对此现象的研究已深入进行 ,具有十分重要的意义。本文就表位扩展的现象、可能机制、重要作用及其影响因素等方面作一简要综述。
All diseases have a development process, in recent years realized that the immune response to antigen is also a plasticity, dynamic, expanding process. Immune response from a epitope for a antigen molecule to multiple epitopes, from one antigen to another antigen gradually diversified phenomenon known as epitope extension (epitopespreading). Epitope extension phenomenon exists in a variety of diseases, especially in the occurrence, development and prognosis of autoimmune diseases, the study of this phenomenon has been carried out in depth, is of great significance. This article gives a brief overview of the phenomenon of epitope expansion, possible mechanism, important role and its influencing factors.