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目的:研究酒蒸黄连总生物碱对实验性糖尿病认知功能障碍动物模型的影响,并初步探讨其机制,为酒蒸黄连总生物碱防治“消渴呆”提供依据。方法:建立四氧嘧啶+东莨菪碱小鼠糖尿病复合认知障碍模型,分别观察药物对小鼠认知功能及糖代谢的影响,初步从抗脂质过氧化的途径探讨其作用机制。结果:酒蒸黄连总生物碱在75~300mg/kg剂量范围内,能明显或部分降低糖尿病小鼠FBG的含量,升高血清Ins的含量,降低HOMA-IR抵抗指数,增加胰岛β细胞FBCI功能指数和胰岛素IAI敏感指数,改善胰岛素抵抗;同时,该药能明显或部分缩短Morris水迷宫实验小鼠的游出时间,延长小鼠避暗实验的潜伏期,减少进入暗室的错误次数,显示出明显的改善认知功能,增强学习记忆能力的作用。上述作用可能与药物降低小鼠脑组织LPO和MDA的含量,升高SOD的活力,抑制脂质过氧化物产生,提高机体对自由基损伤的清除作用有关。结论:酒蒸黄连总生物碱具有抗糖尿病认知功能障碍作用。
OBJECTIVE: To study the effect of alcoholic coptis total alkaloids on experimental diabetic model of cognitive dysfunction, and to explore its mechanism to provide the basis for prevention and cure of alcoholic Coptis alkaloids. Methods: The alloxan + scopolamine diabetic mice model of cognitive impairment were established. The effects of drugs on cognitive function and glucose metabolism were observed. The mechanism of anti-lipid peroxidation was discussed. Results: The ethanol extract of Coptis alkaloids could significantly or partially reduce the content of FBG, increase the content of Ins, decrease the HOMA-IR resistance index and increase the function of pancreatic β-cell FBCI in the range of 75 ~ 300mg / kg Index and insulin IAI sensitive index to improve insulin resistance; the same time, the drug can significantly or partially shorten the swim time in Morris water maze test mice, prolong the incubation period of mice avoidance experiments to reduce the number of errors into the darkroom, showed significant Improve cognitive function, enhance learning and memory ability. The above-mentioned effects may be related to the decrease of LPO and MDA content, the increase of SOD activity, the inhibition of the production of lipid peroxides and the clearance of free radicals in mice. Conclusion: Alcohol distillation Coptis alkaloids have anti-diabetic cognitive dysfunction.