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活血化瘀治则是中医临床抗肿瘤的重要法则之一,活血化瘀中药的抗肿瘤作用也得到大量的研究证实。但近几年实验研究发现某些活血化瘀中药有促进肿瘤转移的作用,从而使活血化瘀中药临床抗肿瘤应用出现争议。破血消癥中药属于活血化瘀药的一种,其效力峻猛,现代研究证实其抗肿瘤作用明显,且进一步的研究发现破血消癥类中药及其有效成分对肿瘤转移具有明显的抑制作用。就破血消癥类中药莪术、三棱、斑蝥、水蛭及其有效成分的抗肿瘤转移作用及其机制研究进行综述,分析认为破血消癥药是一类具有典型抗肿瘤转移作用的活血化瘀药,具有显著的临床应用及开发价值,并认为其抗肿瘤转移实质与影响肿瘤有氧糖酵解的能量代谢密切相关,阐明这一机制可为破血消癥药的临床抗肿瘤及肿瘤转移的应用提供理论指导。
Blood circulation and blood stasis treatment is one of the important principles of clinical anti-tumor medicine. The antitumor effect of traditional Chinese medicine for activating blood circulation and removing blood stasis has also been confirmed by a large number of researches. However, in recent years, experimental studies have found that certain traditional Chinese medicines that promote blood circulation and blood stasis can promote tumor metastasis, so that the clinical anti-tumor application of traditional Chinese medicines for promoting blood circulation and blood circulation is controversial. Blood-clearing and eliminating Chinese medicine belongs to a kind of blood-activating and stasis-removing medicine, its effect is fierce, modern research has proved its anti-tumor effect is obvious, and further study found that blood-clearing and eliminating Chinese medicine and its effective components have obvious inhibition on tumor metastasis effect. This paper reviewed the antitumor metastasis and mechanism of traditional Chinese medicine Curcuma, Tribulus terrestris, Leucaena lemaneiformis and Leech and their effective components in the treatment of blood-dispelling and resolving syndromes. It is concluded that Xue-qi Xiao-qi is a kind of blood-activating agent with typical anti-tumor metastasis Stasis medicine, has significant clinical application and development value, and that its anti-tumor metastasis in essence and affect the energy metabolism of tumor aerobic glycolysis is closely related to clarify that this mechanism can be anti-cancer drugs and clinical anti-tumor and anti-tumor The application of the transfer provides theoretical guidance.