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10多年来在多种药物化疗卵巢生殖细胞恶性肿瘤方面取得了显著进展。以前除了对放射敏感性较高的纯无性细胞瘤有高的治愈率外,其余治愈率均较低。多种药物联台化疗明显地改善了恶性卵巢生殖细胞肿瘤患者的予后。Snmth 和 Rutledge(1975)报告用长春新碱～放射菌素 D—环磷酰胺(VAC)方案,获得高反应率。slagTon 等(1977)报告,以 VAC 方案失败的2例病人,用二线化疗药物长春碱—博莱霉素—顺氯氨铂(VBP)方案有效。
For more than 10 years, remarkable progress has been made in the multi-drug chemotherapy of ovarian germ cell malignancies. In the past, in addition to high radiosensitivity of pure non-malignant cells have a high cure rate, the remaining cure rates were lower. Multiple drug combination chemotherapy significantly improved the prognosis of patients with malignant ovarian germ cell tumors. Snmth and Rutledge (1975) reported a high response rate with the vincristine-actinomycin D-cyclophosphamide (VAC) protocol. slagTon et al. (1977) reported that two patients who failed the VAC regimen were treated with the second-line chemotherapy vinblastine-bleomycin-cisplatin (VBP) regimen.