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由于端粒酶是永生化细胞和绝大多数肿瘤细胞持续分裂增殖的必要条件,因此阻滞端粒酶表达及其活性成为肿瘤治疗的作用靶点,但研究证实仅阻滞端粒酶的活性还不能达到抗肿瘤的理想效果。近期研究发现了肿瘤端粒长度的正调控因子-Tankyrase 1(TANK1),它与端粒延长的抑制因子一端粒结合蛋白Ⅰ(TRF1)共同作用使端粒维持在一特定长度,保证了肿瘤细胞持续生长繁殖。TANK1的发现成为联系端粒酶与TRF1作用的桥梁,由于该酶是调控端粒复制中最为明确的一环,因此成为细胞癌变、肿瘤演进及癌症靶标治疗的新热点。现对TANK1作为分子靶器在肿瘤发生、演进中的作用机制及其在肿瘤治疗领域中的研究进展进行综述。
Because telomerase is a necessary condition for immortalized cells and the vast majority of tumor cells to continue to divide and proliferate, blocking telomerase expression and its activity become targets for tumor therapy, but studies have demonstrated that telomerase alone blocks activity Still can not achieve the desired effect of anti-tumor. Recent studies have found that TANK1, a positive regulator of tumor telomere length, cooperates with TRF1, a telomeric telomere, to maintain telomeres at a specific length and to ensure that tumor cells Continue to grow and reproduce. The discovery of TANK1 becomes a bridge between the role of telomerase and TRF1. Since this enzyme is the clearest part of regulation of telomere replication, it has become a new hot spot in cancer therapy, tumor progression and cancer target therapy. Now TANK1 as a molecular target in tumorigenesis and evolution of the mechanism and its progress in the field of cancer treatment are reviewed.