论文部分内容阅读
本文用放射配体结合分析法测定22例女性肺癌患者外周血白细胞雌激素受体（ER）和雄激素受体（AR）的变化，结果示女性肺癌患者血浆雌二醇（E2）水平育龄期患者明显高于育龄期对照组，绝经期患者与绝经期对照组比较差别无显著性意义。ER均明显增高，AR明显降低，ER／AR比值较年龄匹配的正常对照组明显升高。所有患者血浆睾酮（T）水平均明显低于正常对照组，E2／T比值明显高于对照组，提示性激素及性激素受体的改变在女性肺癌发生发展中起一定作用。
In this paper, radioligand binding assay was used to determine the changes of peripheral blood leukocyte estrogen receptor (ER) and androgen receptor (AR) in 22 women with lung cancer. The results showed that women with lung cancer had estradiol (E2) levels in their reproductive age. Significantly higher than the control group at childbearing age, menopausal patients and menopausal control group showed no significant difference. ER was significantly higher, AR was significantly lower, and ER/AR ratio was significantly higher than that of age-matched normal controls. The plasma testosterone (T) levels in all patients were significantly lower than those in the normal control group, and the E2/T ratio was significantly higher than that in the control group, suggesting that changes in sex hormones and sex hormone receptors play a role in female lung cancer development.