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Formoterol 是一种新的长效β_2激动剂,经动物和人的研究表明,至少它与舒喘灵一样,对β_2肾上腺素受体有选择性作用,口服法的平喘作用是舒喘灵的50倍,吸入法则为舒喘灵的5～15倍,作用时间一般至少为8～12小时.本研究目的在于:比较Formotrol 与舒喘灵的吸入疗法对哮喘患者的疗效.方法选择16(女5、男11)例病情稳定的哮喘患者,平均年龄62(33～69)岁,平均哮喘时间17(2～48)年,1秒钟用力呼气容积(FEV_1)平均为预计值的60%(33～106%),吸入400μg 舒喘灵,FEV_1平均增加28%(16～71%)。
Formoterol is a new long-acting β 2 agonist. Animal and human studies have shown that at least it has the same selective effect on β 2 -adrenoceptors as salbutamol. The antiasthmatic effect of oral administration is salbutamol 50 times, inhalation rule is 5 to 15 times of salbutamol, the role of the time is generally at least 8 to 12 hours.The purpose of this study is: To compare Formotrol and salbutamol inhalation therapy in patients with asthma.Methods Select 16 (female 5, male 11) patients with stable asthma, the average age of 62 (33 to 69) years, the average asthma time of 17 (2 to 48) years, forced expiratory volume per second (FEV_1) an average of 60% (33-106%), inhaled 400μg salbutamol, an average increase of FEV_1 28% (16-71%).