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1例28 d男性新生儿因喘憋2 d、发热1 d由家人喂服对乙酰氨基酚颗粒半包(约0.125 g),半天后患儿病情加重,体温38.1℃,心率273次/min,呼吸43次/nin。呈点头样呼吸,口唇发绀,三凹征(+),双肺可闻及明显干湿啰音,腹部膨隆,肝肋下6 cm。实验室检查:丙氨酸转氨酶(ALT)979 U/L,天冬氨酸转氨酶(AST)1 661 U/L,碱性磷酸酶(ALP)469 U/L,谷氨酰转肽酶(γ-GT)158 U/L,谷氨酰脱氢酶(GLDH)294 U/L,乳酸脱氢酶(LDH)2 989 U/L,α-羟丁酸脱氢酶(α-HBDH)1 141 U/L。诊断为新生儿肺炎并心力衰竭、急性肝损伤。给予抗炎、抗病毒、保肝降酶等治疗。7 d后复查:ALT 72 U/L,AST 32 U/L,ALP 244 U/L,γ-GT 128 U/L,GLDH 31 U/L,LDH 262 U/L。
One case of 28-day male neonates was fed with acetaminophen capsules for half an day (about 0.125 g) due to wheezing for 2 days and fever for 1 day. Half a day later, their condition was aggravated. Body temperature was 38.1 ℃ and heart rate was 273 beats / min. Breath 43 times / nin. Nodded like breathing, cyanotic lips, three concave signs (+), lungs can be heard and obvious wet and dry rales, bulging abdomen, liver ribs 6 cm. Laboratory tests included 979 U / L of ALT, 1 661 U / L of AST, 469 U / L of alkaline phosphatase (ALP), and of glutamyl transpeptidase (γ -GT) 158 U / L, glutamine dehydrogenase (GLDH) 294 U / L, lactate dehydrogenase (LDH) 2 989 U / L, α-hydroxybutyrate dehydrogenase U / L. Diagnosis of neonatal pneumonia and heart failure, acute liver injury. Give anti-inflammatory, anti-virus, liver enzymes and other treatment. After 7 days, the patients were reviewed: ALT 72 U / L, AST 32 U / L, ALP 244 U / L, γ-GT 128 U / L, GLDH 31 U / L and LDH 262 U / L.