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７－氯苄基四氢帕马丁（７－Ｃｌ－ＢＴＨＰ）及奎尼丁（Ｑｕｉ）均能明显延长豚鼠离体左心房的功能性不应期，显著抑制肾上腺素诱发的自律性，但７－Ｃｌ－ＢＴＨＰ能明显增强豚鼠离体左心房的收缩力，而Ｑｕｉ则对其无影响．在心脏肥厚大鼠及正常大鼠的离体主动脉环，７－Ｃｌ－ＢＴＨＰ及Ｑｕｉ对去甲肾上腺素所致的收缩均有抑制作用．７－Ｃｌ－ＢＴＨＰ的ＩＣ５０分别为７６及３９μｍｏｌ·Ｌ－１，而Ｑｕｉ的ＩＣ５０则分别为４．６及８μｍｏｌ·Ｌ－１．Ｑｕｉ对氯化钾所致心脏肥厚及正常大鼠主动脉环的收缩有明显的抑制作用，其ｐＤ２′分别为４．３及４．０，而７－Ｃｌ－ＢＴＨＰ则对其无影响．结果提示７－Ｃｌ－ＢＴＨＰ的抗心律失常作用可能与延长不应期，降低自律性和抗α受体作用有关．
Both 7-Cl-BTHP and Qui could prolong the functional refractory period of isolated left atrium in guinea pigs and significantly inhibit adrenaline-induced autonomicity, but 7 -Cl-BTHP can significantly enhance contractile force of guinea pig isolated left atrium, while Qui has no effect on it. In isolated aortic rings of cardiac hypertrophy rats and normal rats, 7-Cl-BTHP and Qui inhibited noradrenaline-induced contractions. The IC50 of 7-Cl-BTHP was 76 and 39μmol·L-1 respectively, while that of Qui was 4.6 and 8μmol·L-1, respectively. Qui significantly inhibited cardiac hypertrophy induced by potassium chloride and normal rat aortic rings with pD2 ’values of 4.3 and 4.0, respectively, whereas 7-Cl-BTHP did not. The results suggest that anti-arrhythmic effects of 7-Cl-BTHP may be related to prolonged refractory period, decreased self-discipline and anti-α-receptor effect.