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本文研究了溴隐亭(CB_(154))治疗前后病理性高PRL血症对2例绝经妇女促性腺激素(Gn)分泌及潮热的影响。例1,59岁,主诉左侧严重头痛4年。闭经35年无泌乳。CT扫描显示垂体大腺瘤有鞍上的扩张。血浆PRL水平766μg/l,LH7.4IU/1,FSH14.6IU/1。遂服CB~(154)7.5mg/日3周后头痛消失,第4周出现潮热。2月后复查CT肿瘤缩小。PRL下降至34.8μg/l。LH及FSH各上升至31.4及35.2IU/1。改服雌/孕激素(E/P)替代共22个月。潮热消失。PRL17.1μg/l。LH及FSH各为41.5及78.5IU/1。
This study was designed to investigate the effects of bromocriptine (CB_ (154)) on the secretion of gonadotropin (Gn) and hot flashes in 2 postmenopausal women with pathologically high PRL. Example 1,59 years old, complained of severe left headache for 4 years. Amenorrhea 35 years without lactation. CT scans showed pituitary adenoma with dilated suprasellar. Plasma PRL levels 766μg / l, LH7.4IU / 1, FSH14.6IU / 1. Sui service CB ~ (154) 7.5mg / 3 weeks after the headache disappeared, the first 4 weeks of hot flashes. CT review after 2 months to shrink. PRL dropped to 34.8 μg / l. LH and FSH increased to 31.4 and 35.2 IU / 1 respectively. Change service estrogen / progestin (E / P) replacement for a total of 22 months. Hot flashes disappear. PRL 17.1 μg / l. LH and FSH were 41.5 and 78.5 IU / 1 respectively.