用吡喹酮60mg/kg 一次喂饲实验犬后72h 解剖观察。光镜可见虫体皮层有离散和脱落,白细胞浸入体表深处。睾丸、卵巢结构变疏松;透射电镜观察到虫体表皮坏死,皮下细胞膜不清,线粒体固缩。睾丸被膜内层结构不清,细胞核膜断续消失。卵巢细胞膜破损,核膜消失,核内有假包含体;组织化学观察到虫体糖原、核酸等均较服药前明显减少,唯碱性蛋白质溴酚蓝反应增强。 72 hours after the experimental dogs were treated with praziquantel 60mg / kg. Light microscopic parasites caterpillars are discrete and fall off, leukocytes immersed in the depths of the surface. Testicular and ovarian structures became loose; epidermal necrosis of the parasites, unclear cell membrane and mitochondria shrinkage were observed by transmission electron microscope. Testicular capsule inner structure is unclear, intermittent disappearance of the nuclear membrane. Ovarian cell membrane damage, the nuclear membrane disappeared, there are false nuclear inclusions; histochemical observations of parasitoids, nucleic acids, etc. were significantly reduced compared with before treatment, only alkaline protein bromophenol blue reaction enhanced.