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目的探讨短串联重复序列基因座杂合度与攻击行为的关系。方法运用PowerPlex18D System荧光标记复合扩增试剂盒对525例攻击行为军人个体(包括276例主动攻击行为个体和249例被动攻击行为个体)与313例对照样本个体外周静脉血进行PCR复合扩增,然后应用ABI3130XL型基因分析系统对扩增产物进行基因检测。比较三个群体中杂合子比率及17个STR基因座杂度性的差异。结果 17个STR基因座均符合Hardy-Weinberg平衡;三个群体中的杂合子比率差异无统计学意义(P>0.05);在CSF1PO基因座,被动攻击行为组的杂合度显著低于对照组(66.7%vs.74.8%,χ2=4.43,P=0.035);在FGA基因座,主动攻击行为的杂合度显著低于被动攻击行为组(81.9%vs.88.4%,χ2=4.29,P=0.038);其余STR基因座三组的杂合度无统计学意义(P>0.05)。结论 CSF1PO和FGA基因座可能与攻击行为的发生有关;CSF1PO基因杂合性降低可能与被动攻击行为发生相关;FGA基因座杂合性改变可能与攻击行为发生的类型相关。
Objective To investigate the relationship between heterozygosity and aggressive behavior of short tandem repeat loci. Methods 525 cases of aggressive behavior military individuals (including 276 active aggressive individuals and 249 passive aggressive individuals) and 313 peripheral blood samples of control individuals were amplified by PCR using PowerPlex 18D System fluorescent labeling multiplex amplification kit. Then, The ABI3130XL gene analysis system was used to detect the amplified products. Differences in heterozygote ratios and allelic heterozygosity among 17 STR loci were compared among the three populations. RESULTS: All 17 STR loci were in accordance with Hardy-Weinberg equilibrium. There was no significant difference in the heterozygote ratio among the three populations (P> 0.05). The heterozygosity of CSF1PO locus and passive aggression group was significantly lower than that of control group 66.7% vs.74.8%, χ2 = 4.43, P = 0.035). The heterozygosity of active aggression in FGA locus was significantly lower than that in passive aggression (81.9% vs.88.4%, χ2 = 4.29, P = 0.038) There was no significant difference in the heterozygosity among the other three STR loci (P> 0.05). Conclusion The CSF1PO and FGA loci may be related to the aggressive behavior. The reduced heterozygosity of CSF1PO may be related to the passive aggressive behavior. The heterozygous FGA loci may be related to the types of aggressive behaviors.