某些有机磷化合物,特别是三甲苯基磷酸酯(TOCP)可诱发迟缓性神经疾病,环状水杨磷酸酯(PSP)已被证明为TOCP的毒性代谢物.我们在对乙苯基磷酸酯的代谢物研究中,以气质联机方法分别在大鼠和鸡的胆汁中检出了一种类似的环状代谢物,其代谢方式被证明与发生在TOCP中的是一致的,此外,一个产生于ο-甲基化反应的代谢产物也在实验中被检出,文中还就环状代谢物的形成与体内葡萄糖醛酸化反应的关系进行了讨论。 Certain organophosphorus compounds, particularly tricresyl phosphate (TOCP), can induce delayed neuronal disease, and cyclic hydrophosphonate (PSP) has been shown to be a toxic metabolite of TOCP. Metabolites, a similar circular metabolite was detected in the bile of rats and chickens, respectively, using a GC-MS method whose metabolic patterns were shown to be consistent with those occurring in TOCP. In addition, Metabolites on the o-methylation reaction were also detected in the experiment, and the relationship between the formation of cyclic metabolites and the glucuronidation reaction in vivo was also discussed.