对枯氏锥虫的抵抗力及恰加斯病组织损伤病理学的免疫学机制了解甚少。强烈的抗体应答是基本的,胸腺切除和抗淋巴细胞血清的使用可加重感染。用经化学灭活的枯氏锥虫及纯化的虫体糖蛋白均可诱导部分保护性免疫,为了检查L3T4~+(CD4~+)T淋巴细胞抗枯氏锥虫的作用机制,做了以下试验:枯氏锥虫上鞭毛体用含2％葡萄糖PBS冲洗,悬浮于蒸馏水中,冰浴超声粉碎后 Little is known about the resistance to Trypanosoma cruzi and the immunological mechanisms of Chagas disease histopathology. Intense antibody responses are essential and use of thymectomy and anti-lymphocyte serum can aggravate the infection. In order to examine the mechanism of action of L3T4 ~ + (CD4 ~ +) T lymphocytes against Trypanosoma cruzi, chemically-activated Trypanosoma cruzi and purified worm glycoprotein can induce partial protective immunity, the following Test: Trypanosoma cruzi on flagella with 2% glucose PBS rinse, suspended in distilled water, ultrasonic bath after ice bath