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目的 分析比较用同样剂量的氨甲喋呤 (MTX)采用单次静注和分次静注治疗异位妊娠的疗效及安全性。方法 选择 66例异位妊娠患者 ,随机分为A、B两组。A组 32例 ,采用MTX 10 0mg加生理盐水2 0ml单次静注 ,然后再静滴生理盐水 80ml;B组 34例 ,采用MTX 2 0mg加生理盐水 2 0ml,每天 1次静注 ,,连用 5d。总量 10 0mg为 1个疗程。结果 A组 2 9例治疗成功 ,成功率 90 .6% ,B组 2 8例治疗成功 ,成功率84 .4 %。两组治疗成功率差异无显著性 (P >0 .0 5 ) ,副反应差异无显著性 (P >0 .0 5 ) ,但血 β -hCG下降至正常的时间差异有极显著性 (P <0 .0 1) ,平均住院日差异有极显著性 (P <0 .0 1)。结论 早期诊断和严格选择病例是治疗异位妊娠成功的关键 ;MTX单次静脉注射治疗异位妊娠 ,可缩短住院时间 ,节省费用 ,优于分次静脉注射
Objective To compare the efficacy and safety of methotrexate (MTX) with single intravenous injection and divided intravenous injection in the treatment of ectopic pregnancy with the same dose. Methods Sixty-six patients with ectopic pregnancy were randomly divided into A and B groups. A group of 32 cases, using MTX 10 0mg saline 20ml single intravenous injection, and then intravenous infusion of 80ml; B group 34 cases, using MTX 20mg saline 20ml once daily intravenous ,, 5d. The total amount of 10mg for a course of treatment. Results A group of 29 cases were successfully treated with a success rate of 90.6%. In group B, 28 cases were successfully treated with a success rate of 84.4%. There was no significant difference in the success rate of treatment between the two groups (P> 0.05), but there was no significant difference in side effects (P> 0.05), but there was a significant difference in the time between the decrease of β -hCG and normal blood (P <0. 01), the average length of stay was significantly different (P <0.01). Conclusion Early diagnosis and strict selection of cases is the key to the success of treatment of ectopic pregnancy; MTX single intravenous injection of ectopic pregnancy can reduce hospitalization time and save costs, superior to fractionated intravenous injection