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目的观察消郁安神胶囊对大鼠的长期安全性影响。方法大鼠连续灌胃消郁安神胶囊90、180d和停药30d,与正常对照组比较病理学检查结果。结果消郁安神各剂量组药后5～20min动物自主活动有所减弱,30min后自主活动逐渐恢复正常,各剂量组大小便颜色偏深,高剂量组比较明显,停止给药后,上述症状均恢复正常。动物血液细胞学、生化学指标中有个别指标在给药初期(即90d)出现明显差异,继续给药180d,未见明显异常,停止给药后恢复正常;高剂量组动物体质量有一定降低,个别脏器质量及指数增大,停药30d后均能恢复正常;病理检查结果示,消郁安神各剂量组主要脏器未见由药物引起的病理学改变;整个实验期间各组动物未见死亡。结论大鼠长期给予消郁安神胶囊的安全剂量为40.0g/kg,对动物的毒性较低。
Objective To observe the long-term safety of Xiao Yu Anshen Capsule in rats. Methods Rats were continuously treated with Xiaoyan Anshen Capsules for 90,180 days and drug withdrawal for 30 days. Pathological examination results were compared with those of normal control group. Results Depression and soothe the nerves in each dose group decreased from 5 to 20 minutes after drug administration. After 30 minutes, spontaneous activity returned to normal gradually. The color of urine in each dose group was darker in color and obvious in the high-dose group. After stopping administration, Back to normal. Animal blood cytology, biochemical indicators of some indicators early in the administration (ie 90d) showed significant differences, continue to be administered 180d, no obvious abnormalities, stopped returning to normal after treatment; high-dose group of animals have a certain decrease in body weight , The quality and index of some organs increased and returned to normal after 30 days of withdrawal. The results of pathological examination showed that there were no pathological changes caused by drugs in the main organs of each dose group in the treatment of depression and soothing. In the whole experiment, See death. Conclusions The long-term safety dose of Xiao Yu Anshen Capsule is 40.0g / kg, which is less toxic to animals.