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1 定义 多年来,我们接受了哮喘的不同定义。目前,大多数人接受的定义是:哮喘是一种涉及多种细胞相互作用的一种慢性炎症(非炎症性炎症)疾病。这些细胞释 放大量炎性介质,激活气道靶细胞,引起支气管痉挛、微血管渗漏,粘膜水肿,粘液分泌亢进和神经反射兴奋。大部分人提议气管高反应性是哮喘的主要特点。目前有研究人员宣称气管高反应性由炎症引起,炎症是哮喘的疾病基础。人们已愈来愈了解过敏、感染、介质分泌、精神因素、植物神经失衡等最终会导致哮喘的各因素之间复杂的相互作用。
1 Definitions For many years we have accepted different definitions of asthma. Currently, most people accept the definition that asthma is a chronic inflammatory (non-inflammatory) disease involving a variety of cell-cell interactions. These cells release large amounts of inflammatory mediators, activating airway target cells, causing bronchospasm, microvascular leakage, mucosal edema, hypersecretion of mucus, and excitement of reflexes. Most people suggest that tracheal hyperresponsiveness is a major feature of asthma. At present, some researchers claim that tracheal hyperreactivity is caused by inflammation, which is the basis of the disease of asthma. There is a growing understanding of the complex interactions between the various factors that lead to asthma, such as allergies, infections, media excretion, psychiatric disorders, and autonomic imbalance.