目的研究survivin基因在乳腺癌中的表达及其与HER-2、突变型p53的关系。方法免疫组化法检测62例乳腺癌组织中survivin、HER-2、p53基因的表达。结果62例乳腺癌组织中survivin、p53阳性率分别为67.7%、35.5%;HER-2过度表达率37.1%。Survivin表达水平与患者临床病理特征及p53表达均无相关性(P>0.05),与HER-2过度表达相关(P=0.013)。结论Survivin表达水平与HER-2过度表达相关;HER-2基因可能与survivin基因之间可能存在某种调控通路。 Objective To study the expression of survivin gene in breast cancer and its relationship with HER-2 and mutant p53. Methods Immunohistochemistry was used to detect the expression of survivin, HER-2 and p53 in 62 cases of breast cancer. Results The positive rates of survivin and p53 in 62 cases of breast cancer were 67.7% and 35.5%, respectively. The overexpression rate of HER-2 was 37.1%. There was no correlation between the expression of Survivin and the clinicopathological features and p53 expression (P> 0.05), which was correlated with the overexpression of HER-2 (P = 0.013). Conclusion The expression of Survivin is correlated with HER-2 overexpression. There may be some regulatory pathway between HER-2 gene and survivin gene.