已知抗有丝分裂剂对免疫系统具有阻抑作用,且常有利于器官移植和免疫中介疾病的治疗。与此相反,尽管抗微生物药物对细胞中介免疫和体液免疫两者的许多作用已被认识,但却大大忽视了临床应用中它们对免疫系统的作用。由于抗微生物化疗通常时间短,关于这方面的观察可能较少。但结核病、麻疯病、深部臂骨感染、全身性霉菌感染、普通痤疮、风湿热的予防和复发性尿路感染却需要持久的治疗。免疫机制对这些情况下的几种致病原 Anti-mitotic agents are known to suppress the immune system and are often beneficial for the treatment of organ transplant and immune-mediated diseases. In contrast, although many of the effects of antimicrobial drugs on both cell-mediated and humoral immunity have been recognized, their role in the immune system in clinical applications has been largely neglected. Because antimicrobial chemotherapy is usually short, observations in this area may be less. But tuberculosis, leprosy, deep arm bone infections, systemic fungal infections, acne vulgaris, prevention of rheumatic fever and recurrent urinary tract infections require long-term treatment. Immune mechanisms against several causative agents in these situations