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本文应用微核试验观察了胃癌62例，胃良性疾病53例，正常人12例周围血淋巴细胞微核出现率。胃癌组、胃良性疾病组和正常组平均微核细胞阳性率分别为1．56‰，07％‰和0．58‰，三组间差异显著（Prto．001）；三组平均做核率分别为1．82‰0．8‰和0．6‰，（P＜0．05）；不同类型和不同分化程度的胃癌微核细胞阳性率与微核率无明显差异（P＞0．05）；胃良性疾病组中胃溃疡，慢性胃炎和正常人平均微核细胞阳性率与微核率亦无明显差异（P＞0．05）。结果提示胃癌患者不仅胃局部，而且全身各种细胞均存在突变现象；因此，周围血淋巴细胞微核试验适用于筛选致胃癌及其它各种癌的化学物。
In this paper, micronucleus test was used to observe 62 cases of gastric cancer, 53 cases of benign gastric disease, and 12 cases of normal human lymphocytes. The average positive rates of micronuclei in gastric cancer group, benign gastric disease group and normal group were 1.56‰, 70%‰ and 0.58‰, respectively. There was significant difference among the three groups (Prto.001). It was 1.82‰0.8‰ and 0.6‰ (P<0.05). There was no significant difference in the positive rate and micronucleus rate of gastric cancer between different types and different degrees of differentiation (P>0.05). There was no significant difference in the average micronucleus cell positive rate and micronucleus rate between gastric ulcer, chronic gastritis and healthy people in the benign gastric disease group (P>0.05). The results suggest that there are mutations in gastric cancer patients not only in the gastric region but also in various body cells; therefore, the peripheral blood lymphocyte micronucleus test is suitable for the screening of gastric cancer and other various cancer chemicals.