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目的 探讨宫颈阴道分泌物非磷酸化胰岛素样生长因子结合蛋白 1(IGFBP 1)在胎膜早破诊断中的临床价值。方法 2 0 0 2年 1月至 2 0 0 3年 6月采用快速层析法对 59例确诊或疑似胎膜早破孕妇和 40例正常孕妇宫颈阴道分泌物进行IGFBP 1检测。结果 应用IGFBP 1诊断胎膜早破的准确率、敏感性和特异性分别为10 0 0 %、10 0 0 %、90 9%和 98 3 %。检测IGFBP 1的敏感性、阴性预测值和精确度均显著高于羊齿状结晶法和pH值法。 结论 宫颈阴道分泌物IGFBP 1的检测可用于诊断胎膜早破 ,具有操作简便、快速和准确的特点 ,对临床确诊胎膜早破具有较大的实用价值
Objective To investigate the clinical value of non-phosphorylated insulin-like growth factor binding protein-1 (IGFBP 1) in cervical vaginal secretions in the diagnosis of premature rupture of membranes. METHODS: From January 2002 to June 2003, 59 patients with confirmed or suspected premature rupture of membranes and 40 normal pregnant women were examined for IGFBP-1 by flash chromatography. Results The accuracy, sensitivity and specificity of IGFBP 1 in the diagnosis of premature rupture of membranes were 100%, 100%, 90% and 98% respectively. The sensitivity, negative predictive value and accuracy of IGFBP 1 detection were significantly higher than those of sheep dentate crystallization and pH values. Conclusion The detection of cervical vaginal secretions IGFBP 1 can be used to diagnose premature rupture of membranes. It has the characteristics of simple, rapid and accurate operation. It has great practical value for diagnosing premature rupture of membranes