目的:探讨新生儿窒息发生的高危因素,及时采取有效的防范措施,以降低窒息发生率及减轻窒息程度。方法:收集我院2008年8月至2011年8月分娩的新生儿1353例,分析新生儿窒息的高危因素。结果:有明确高危因素者占50.8%,其中,羊水因素居首位,其次依次为脐带因素、胎位异常、母亲因素及胎盘因素等,窒息严重程度与羊水污染及脐带、胎位异常有明显相关性,羊水污染越重,新生儿窒息发生率越高。结论:加强监护及产儿科合作,出现羊水Ⅲ°污染时立即终止妊娠,正确处理各种高危因素,可有效降低新生儿窒息的发生率。 Objective: To investigate the risk factors of neonatal asphyxia and to take timely and effective preventive measures to reduce the incidence of asphyxia and reduce the degree of asphyxia. Methods: A total of 1353 newborns were delivered in our hospital from August 2008 to August 2011, and the risk factors of neonatal asphyxia were analyzed. Results: There were 50.8% patients with definite risk factors, of which amniotic fluid ranked the first place, followed by umbilical cord factors, fetal position abnormalities, maternal factors and placenta factors. The severity of asphyxia was significantly associated with amniotic fluid contamination, umbilical cord and fetal position abnormalities , The more amniotic fluid pollution, the higher the incidence of neonatal asphyxia. Conclusion: Intensive monitoring and pediatric cooperation in the department of gynecology, termination of pregnancy immediately after the amniotic fluid Ⅲ ° contamination occurs, and proper treatment of various risk factors can effectively reduce the incidence of neonatal asphyxia.