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背景:吸毒行为是吸毒者感染乙型肝炎病毒(hepatitisBvirus,HBV)和丙型肝炎病毒(hepatitisCvirus,HCV)感染的主要原因,女性吸毒者吸毒行为有其自身特点,这些特点与HBV,HCV重叠感染有何关系?目的:了解不同吸毒特点与女性吸毒者HBV,HCV重叠感染率的关系。设计:2002-01进行的以女性吸毒者为研究对象的横断面调查。单位:一所市级医院检验科,一所大学的公共卫生学院流行病学教研究室,一所专业戒毒所。对象:整群抽取株洲市白马垅戒毒所320名女性吸毒人员为调查对象。方法:用自编问卷调查吸毒者吸毒特点,用ELISA法测定其血清中乙型肝炎病毒表面抗原(HBsAg)及抗丙型肝炎病毒抗体(抗-HCV)。主要观察指标:吸毒者HBV,HCV重叠感染与注射吸毒、吸毒年限、吸毒时间、戒毒次数之间的关系。结果:320份血清HBsAg和抗-HCV重叠感染率9.37%,全部为注射毒品者,与非注射吸毒者比较,差异有显著性(χ2=6.276,P<0.05);吸毒年限越长,重叠感染率越高,吸毒时间1～5年与5～10年组的重叠感染率(4.5%和10.3%)差异有显著性(χ2=8.344,P<0.05);戒毒次数≤3次与戒毒次数≥4次的重叠感染率差异有显著性(χ2=9.418,P<0.05);吸毒年限、戒毒次数是影响女性吸毒者HBV、HCV重叠感染的主要因素(OR=1.923,1.597;95%CI=0.964～3.838,0.962～2.652)。?
BACKGROUND: Drug abuse is the main reason for drug addicts being infected with hepatitis B virus (HBV) and hepatitis C virus (HCV). Female drug addicts have their own characteristics of drug abuse. These characteristics overlap with that of HBV and HCV What is the relationship? Objective: To understand the relationship between different drug use characteristics and female drug users HBV, HCV overlap infection rate. Design: A cross-sectional survey of female drug users in 2002-01. Unit: a municipal hospital laboratory, a university public health college epidemiology teaching laboratory, a professional detoxification center. PARTICIPANTS: A total of 320 female drug addicts from Zhuhai Baima Ji detoxification center were selected as the survey subjects. Methods: The self-made questionnaires were used to investigate the characteristics of drug addicts. The serum HBsAg and anti-HCV antibodies (anti-HCV) were determined by ELISA. MAIN OUTCOME MEASURES: The relationship between drug addicts HBV, HCV overlap infection and injecting drug use, drug addiction time, drug addiction time, drug addiction frequency. Results: The overlap rates of HBsAg and anti-HCV in 320 serum samples were 9.37%, all of which were drug injectors. There was significant difference between non-injecting drug users and non-injecting drug users (χ2 = 6.276, P <0.05) The higher the rate, the overlap infection rates (4.5% and 10.3%) between 1 to 5 years and 5 to 10 years were significant (χ2 = 8.344, P <0.05) (Χ2 = 9.418, P <0.05). The duration of drug abuse and the frequency of drug abuse were the main factors influencing the overlap of HBV and HCV infection among female drug users (OR = 1.923,1.597; 95% CI = 0.964 ~ 3.838, 0.962 ~ 2.652). ?