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本组通过双抗体夹心ELISA法,检测病毒性心肌炎急性期52例、恢复期42例、慢性期18例血清可溶性白介素-2受体(sIL-2R)、肿瘤坏死因子-α(TNF-α)活性,探讨其在发病中的作用。结果显示:sIL-2R在急性期、慢性期显著升高(P<0.001),恢复期与对照组无显著差别;TNF-α在急性期、恢复期、慢性期均高于对照组,且以急性期为显著(P<0.001)。提示sIL-2R、TNF-α参与心肌炎发病的全过程,其sIL-2R的变化与转归有关;而慢性患儿的sIL-2R、TNF-α活性增高,是否与发展为扩张性心肌病有关,需待进一步研究。
In this study, 52 cases of acute viral myocarditis, 42 cases of recovery, 18 cases of serum soluble interleukin-2 receptor (sIL-2R), tumor necrosis factor-α (TNF-α) Activity, to explore its role in the pathogenesis. The results showed that sIL-2R was significantly increased in acute phase and chronic phase (P <0.001), and there was no significant difference between recovery phase and control group. The levels of TNF-α in acute phase, recovery phase and chronic phase were higher than those in control group Acute phase was significant (P <0.001). These results suggest that sIL-2R and TNF-α are involved in the pathogenesis of myocarditis, and the changes of sIL-2R are related to prognosis. However, the activity of sIL-2R and TNF-α in chronic children is increased, which is related to the development of dilated cardiomyopathy , Needs further study.