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目的:观察血浆D-二聚体(D-dimer,DD)和血清脂蛋白(a)[Lp(a)]在糖尿病肾病(DN)中的变化并 探讨两者之间的关系。方法:根据尿白蛋白排泄率(UAER)将126例2型糖尿病(DM)患者分为单纯糖尿病组(SDM 组)、早期糖尿病肾病组(EDN组)和临床糖尿病肾病组(CDN组),45名健康者作为对照组,分别测定各组血浆DD和 血清Lp(a)的水平。结果:DD、Lp(a)水平SDM组与对照组比较无统计学差异(P>0.05),但EDN和CDN组显著高 于SDM组和对照组(P<0.01),CDN组显著高于EDN组(P<0.01)。DD和Lp(a)分别与UAER呈显著正相关(r= 0.523,0.426,P<0.01)。结论:DN患者血浆DD和血清Lp(a)水平随着UAER的增加而升高,两者之间关系密切,可 能与DN的进展有关。
Objective: To observe the changes of plasma D-dimer (DD) and serum lipoprotein (a) [Lp (a)] in diabetic nephropathy (DN) and to explore the relationship between the two. Methods: One hundred and twenty-six patients with type 2 diabetes mellitus (DM) were divided into diabetic group (SDM group), early diabetic nephropathy group (EDN group) and clinical diabetic nephropathy group (CDN group) according to urinary albumin excretion rate (UAER) Healthy controls were used as the control group to determine the level of plasma DD and serum Lp (a) in each group. Results: There was no significant difference between DD and Lp (a) levels in SDM group and control group (P> 0.05), but EDN and CDN group were significantly higher than those in SDM group and control group (P <0.01) Group (P <0.01). There was a significant positive correlation between DD and Lp (a) and UAER (r = 0.523,0.426, P <0.01). Conclusion: The levels of plasma DD and serum Lp (a) in patients with DN are increased with the increase of UAER, which are closely related to the progression of DN.