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目的:中枢损伤是目前致残率最高的疾病之一,肌苷对于神经损伤后功能恢复的促进作用已经成为研究热点,本研究拟建立一侧前肢瘫痪的大鼠脑外伤模型,证实肌苷治疗促进中枢损伤后上肢功能恢复的有效性,同时初步探索其机制。方法:建立一侧运动皮层冲击损毁的大鼠模型,通过肢体不对称实验、抓取实验等行为学观察证实其患侧上肢功能受损,后在实验组进行肌苷药物14天,观察28天内上肢功能的恢复情况,与对照组作对比,证实其行为学上的有效性,同时对损伤侧大脑进行顺行BDA染色,探索其内在机制。结果:通过28天的观察发现经过肌苷治疗的的实验组大鼠肢体不对称实验、抓取实验等行为学评分明显好于隐性对照组,顺行BDA染色证实其有促进损伤周围健存皮层突触再生和代偿的作用。结论:肌苷可以促进中枢损伤后大鼠残存神经元得突触再生,使其大脑能在最大程度上代偿其丧失的功能,该药物可能会成为一种新的中枢损伤治疗的前体药物。
Objective: Central injury is one of the most morbidly disabling diseases. The promotion of inosine on the functional recovery after nerve injury has become a research hotspot. In this study, a model of traumatic brain injury in frontal paralysis in rats was established to confirm that inosine treatment Promote the recovery of upper limb function after central injury, and explore its mechanism at the same time. Methods: A rat model of motor cortex shock damage was established. The limb dysfunction was confirmed by behavioral observation of limb asymmetry, grasping and so on. The rats in the experimental group were treated with inosine for 14 days and observed for 28 days The recovery of upper extremity function was compared with that of the control group to confirm its behavioral validity. At the same time, BDA staining was performed on the injured side of the brain to explore its intrinsic mechanism. Results: Through the observation of 28 days, we found that the inosine group treated with inosine treatment had significantly better behavioral scores than the control group, such as limb asymmetry test and BDA staining. Cortical synapse regeneration and compensatory role. CONCLUSION: Inosine can promote synaptic regeneration of the remnant neurons in rats after central injury, so that the brain can maximally compensate for the loss of function. The drug may become a new prodrug for central injury treatment .