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本研究前瞻性双盲随机比较单用硬化剂疗法与合用奥曲肽在控制肝硬化曲张静脉急性破裂出血和预防早期再出血的效果。 病人与方法:因呕血和黑便而入院的成人患者如内镜下见食管或贲门曲张静脉有活动性出血(喷血或渗血)、或曲张静脉虽已无出血但消化道无其他部位出血的证据而且呕血或黑便发生至急诊内镜检查不到24小时者随机接受研究;肝硬化根据肝活检或典型实验室检查结果和临床表现确诊。 治疗:硬化剂治疗后,立即经注射泵滴注25μg/h奥曲肽或安慰剂,并维持120小时。 结果:199例急诊接受硬化剂治疗者进入本研究,其中奥曲肽组98例,安慰剂组101
This study was a prospective, double-blind, randomized, double-blind, randomized comparison of sclerosant therapy with octreotide in the management of acute rupture of varicose vein cirrhosis and prevention of early rebleeding. Patients and methods: adult patients admitted to hospital for hematemesis and melena, such as endoscopic bleeding in the esophagus or varicose veins with active bleeding (spitting or bleeding), or bleeding in other parts of the digestive tract without variceal bleeding Of the evidence and hematemesis or melena occurred to the emergency endoscopy less than 24 hours were randomized to study; liver cirrhosis based on liver biopsy or typical laboratory findings and clinical manifestations confirmed. Treatment: Immediately after sclerotherapy treatment, 25 μg / h of octreotide or placebo was administered via syringe pump and maintained for 120 hours. RESULTS: A total of 199 patients receiving sclerotherapy were enrolled in this study. 98 patients in the octreotide group and 101 in the placebo group