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目的探讨血清超敏C反应蛋白(hs-CRP)的含量变化在冠心病中的临床应用。方法随机选取90例冠心病患者作为观察组,其中急性心肌梗死(AMI)、不稳定型心绞痛(UAP)、稳定型心绞痛(SAP)各30例,并选取32例健康人作为对照组。采用乳胶增强免疫透射比浊法检测两组患者血清中hs-CRP含量,并分析比较观察组治疗前后hs-CRP含量的变化。结果治疗前,AMI、UAP、SAP三组的血清hs-CRP含量(3.28±1.26;6.68±2.75;12.92±4.78)显著高于对照组(0.98±0.76);治疗后,AMI、UAP、SAP三组的血清hs-CRP含量(1.96±0.86;3.64±1.52;7.22±3.11)显著低于各组治疗前水平,结果均具有统计学意义(P<0.05)。结论血清hs-CRP水平的变化与冠心病的发生、发展密切相关,对其检测有助于冠心病患者的诊断、疗效观察及预后的判断。
Objective To investigate the clinical application of the content of serum hs-CRP in coronary heart disease. Methods Ninety patients with coronary heart disease were randomly divided into observation group, 30 cases of acute myocardial infarction (AMI), unstable angina pectoris (UAP) and stable angina pectoris (SAP). 32 healthy subjects were selected as control group. The contents of hs-CRP in serum of two groups were detected by latex-enhanced immunoturbidimetry, and the changes of hs-CRP in the observation group before and after treatment were analyzed. Results Before treatment, the levels of hs-CRP in AMI, UAP and SAP groups were significantly higher than those in control group (3.28 ± 1.26; 6.68 ± 2.75; 12.92 ± 4.78) The levels of serum hs-CRP (1.96 ± 0.86; 3.64 ± 1.52; 7.22 ± 3.11) were significantly lower than those before treatment in each group. The results were statistically significant (P <0.05). Conclusion The change of hs-CRP in serum is closely related to the occurrence and development of coronary heart disease. The detection of hs-CRP is helpful to the diagnosis, curative effect and prognosis of patients with coronary heart disease.