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目的观察小剂量泼尼松干预5-氨基酮戊酸光动力治疗尖锐湿疣过程中所产生疼痛的作用。方法试验组51例,在照光前0.5 h给予小剂量泼尼松20 mg口服;对照组49例,照光前不服用任何药物。采用NRS(numeric rating scale)评分法记录两组患者在照光3、5、10、15、20 min的疼痛分值,比较两组5个时间点中最高的疼痛评分值;并于末次治疗后1、2、4、12、24周进行疗效评估,比较两组治疗后的复发情况。结果照光期间所产生的疼痛以局部浅表的灼痛和刺痛为主要特征,两组最高疼痛评分中位数比较,差异有统计学意义(P<0.05)。试验组和对照组治愈率分别为80.4%和81.6%,复发率分别为19.6%和18.4%,差异均无统计学意义(P>0.05)。结论小剂量泼尼松可缓解5-氨基酮戊酸光动力治疗尖锐湿疣照光过程中所产生的疼痛,不影响临床疗效。
Objective To observe the effect of low dose prednisone intervention on the pain induced by 5-aminolevulinic acid photodynamic therapy in condyloma acuminatum. Methods Fifty-one patients in trial group were given low-dose prednisone 20 mg orally 0.5 h before irradiation. In control group, 49 patients were given no medication before light irradiation. NRS scores were used to record the pain scores of the two groups at 3, 5, 10, 15 and 20 min after irradiation, and the highest pain scores were compared between the two groups at 5 time points. After the last treatment 1 , 2,4,12,24 weeks efficacy evaluation, comparison of two groups after treatment relapse. Results The pain in the light period was mainly characterized by the burning and tingling of the superficial local surface. The median of the highest pain scores of the two groups was statistically significant (P <0.05). The cure rates of the experimental group and the control group were 80.4% and 81.6%, respectively, and the recurrence rates were 19.6% and 18.4% respectively, with no significant difference (P> 0.05). Conclusions Low-dose prednisone can relieve the pain caused by photodynamic therapy of 5-aminolevulinic acid in condyloma acuminatum without affecting clinical curative effect.