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为进一步澄清干扰素治疗慢性丙型肝炎应答的预测因素,作者在1988年4月～1991年12月间对111例接受干扰素(IFN)治疗的慢性丙型肝炎患者的几种变异因素的预测价值进行了单变量和多变量分析研究。 全部病例均接受α-2a IFN治疗。Ⅰ组(17例):2 MU,每周3次,共16周(总剂量96 MU),肌注。Ⅱ组(25例):4MU,每周3次,共16周(总剂量192MU)。Ⅲ组(47例):6MU,每周3次,共16周(总剂量288MU)。Ⅳ组(22例):6MU,每周6次,共2周;随后每周3次,共22周(总剂量468MU)。ALT在治疗期间或治
To further elucidate the predictors of interferon therapy for chronic hepatitis C, we predicted several variables in 111 patients with interferon (IFN) -mediated chronic hepatitis C between April 1988 and December 1991 The values were univariate and multivariate analysis studies. All cases received α-2a IFN treatment. Group Ⅰ (17 cases): 2 MU, 3 times a week, a total of 16 weeks (total dose of 96 MU), intramuscular injection. Group II (25 cases): 4MU, three times a week for a total of 16 weeks (total dose of 192MU). Group Ⅲ (n = 47): 6MU, three times a week for a total of 16 weeks (total dose 288MU). Group IV (n = 22): 6MU 6 times per week for 2 weeks followed by 3 times per week for a total of 22 weeks (total dose 468MU). ALT during treatment or treatment