新型免疫抑制剂麦考酚酸酯（ｍｙｃｏｐｈｅｎｏ－ｌａｔｅ 　ｍｏｆｅｔｉｌ， ＭＭＦ）是麦考酚酸（ｍｙｃｏｐｈｅｎｏｌｉｃ ａｃｉｄ，ＭＰＡ）的２－乙基酯类衍生物，在体内脱酯化后形成具有免疫抑制活性的代谢产物ＭＰＡ，后者通过抑制鸟嘌呤的合成，选择性阻断Ｔ和Ｂ淋巴细胞的增殖，对移植排异和自身免疫性疾病均有显著疗效。临床上已应用于器官移植和自身免疫性疾病，且副作用少，显示了良好的应用前景。本文对其作用机制、药物动力学及临床应用等方面进行了综述。 Mycophenolate late mofetil (MMF), a novel immunosuppressive agent, is a 2-ethyl ester derivative of mycophenolic acid (MPA) that is deesterified in vivo to form an immunosuppressive Metabolites MPA, the latter by inhibiting the synthesis of guanine, selectively blocking the proliferation of T and B lymphocytes, transplant rejection and autoimmune diseases have a significant effect. Clinic has been applied to organ transplantation and autoimmune diseases, and fewer side effects, showing a good prospect. This article reviews its mechanism of action, pharmacokinetics and clinical application.