类风湿性关节炎(RA)是一种以周围关节病变为主的全身性疾病。近年来认为与遗传有关,但 RA 家族史不明显,本文系报告同属一个家系的6例患者。例1:男性,41岁,住院号14932。因关节肿疼23年,心悸8个月,再发14小时。于1986年5月26日住院。18岁时发生左膝关节肿疼、发热。口服强的松、注射辛可芬治疗3个月,关节肿疼缓解。33岁时发生右手多个手指近侧指间关节、腕关节红肿剧疼。近4年来上述关节周围逐渐出现多个大小不等的结节,硬如橡皮,可自行变小,病后经常服安乃近、炎痛喜康、布洛芬等,近6年年来每月服强的松4～6片。8个月前逐渐发生活动后心悸、闷气,下肢浮肿,5个月前因受凉发生咳嗽、吐痰5天,继之呼吸困难,不能平卧,咳嗽吐泡 Rheumatoid arthritis (RA) is a systemic disease characterized mainly by peripheral joint disease. In recent years that genetic and RA, but family history is not obvious, this article is reported in the same family of 6 patients. Example 1: Male, 41 years old, hospital number 14932. Because of joint swelling and pain for 23 years, palpitations 8 months, the re-issued 14 hours. In May 26, 1986 was hospitalized. At the age of 18 left knee joint pain, fever. Oral prednisone, Sinocorte injection for 3 months, joint swelling and pain relief. 33-year-old right hand multiple finger proximal interphalangeal joint, wrist pain and swelling. Over the past 4 years, the above joints gradually appear multiple nodules of different sizes, hard as rubber, can become smaller, often served after the illness of the Annapurna, Yikong Xikang, ibuprofen, etc., nearly six years every month Strong prednisone 4 to 6 tablets. 8 months ago after the event of activity palpitations, stuffy, lower extremity edema, cough caused by the cold 5 months ago, spit 5 days, followed by breathing difficulties, can not lie down, coughing bubble