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目的研究甲磺酸帕珠沙星对兔体内氨茶碱药动学的影响。方法采用自身对照法,以HPLC测定兔单用氨茶碱及与甲磺酸帕珠沙星合用后的茶碱血清浓度,计算药动学参数。结果经BAPP2.3药动程序拟合,甲磺酸帕珠沙星使兔血清中茶碱的曲线下面积AUC由152.0mg·h·L-1增加到361.4mg·h·L-1;半衰期t1/2由2.292h延长至6.823h;MRT由4.944h延长到9.383h,均有非常显著性差异(P<0.01)。结论家兔体内合用甲磺酸帕珠沙星对氨茶碱的消除药动学有显著抑制作用。
Objective To study the effect of pazufloxacin mesylate on aminophylline pharmacokinetics in rabbits. Methods The pharmacokinetic parameters of aminophylline in rabbits and theophylline in combination with pazufloxacin mesylate were determined by HPLC. Results The AUC of theophylline in rabbit serum was increased from 152.0mg · h · L-1 to 361.4mg · h · L-1 by Pazufloxacin mesylate by the BAPP2.3 pharmacokinetic program. The half-life t1 / 2 prolonged from 2.292h to 6.823h; MRT prolonged from 4.944h to 9.383h, there was a very significant difference (P <0.01). Conclusion Pazufloxacin mesylate in rabbits can significantly inhibit the aminophylline pharmacokinetics.