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狼疮肾炎(LN)是系统性红斑狼疮(SLE)最常见的并发症,约有60%的系统性红斑狼疮患者可伴有狼疮肾炎,约有5%~20%的狼疮肾炎患者可发展为终末期肾脏病(ESRD),最终导致死亡。趋化因子作为炎症与免疫反应的桥梁,参与了多种肾脏疾病的发生发展。本文主要介绍IFN-γ诱导型趋化因子CXCL9、CXCL10、CXCL11在狼疮肾炎发生发展以及辅助性诊断中的作用,以寻求狼疮肾炎诊断治疗中的新途径。
Lupus nephritis (LN) is the most common complication of systemic lupus erythematosus (SLE). About 60% of patients with systemic lupus erythematosus may be associated with lupus nephritis, and about 5% to 20% of lupus nephritis patients develop into a terminal End-stage renal disease (ESRD) eventually leads to death. As a bridge between inflammation and immune response, chemokines are involved in the development of various kidney diseases. This article describes the IFN-γ-induced chemokines CXCL9, CXCL10, CXCL11 in the occurrence and development of lupus nephritis and adjuvant diagnosis in order to seek new ways of diagnosis and treatment of lupus nephritis.