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合成的黄体生成素释放激素拮抗类似物（ＴＸ５１）具有很强的抑制黄体生成素（ＬＨ）及甾体性激素（睾酮Ｔ、雌二醇Ｅ２）的分泌作用［１］，本研究目的在于评价该化合物对成年雌、雄恒河猴的ＬＨ及Ｅ２的基础分泌及给予２５μｇＬＨＲＨ后所激起的ＬＨ、Ｔ释放的抑制效应，结果提示ＴＸ５１是一种高活性的抑制性腺内分泌的化合物。
Synthetic luteinizing hormone releasing hormone antagonist (TX51) has a strong inhibitory effect on the secretion of luteinizing hormone (LH) and steroid hormones (testosterone T, estradiol E2) [1]. The purpose of this study was to evaluate the The inhibitory effect of the compound on the basal secretion of LH and E2 and the LH and T release provoked by 25 μg LHRH in adult males and males suggests that TX51 is a highly active and inhibitory glandular endocrine compound.